Thiamine nitrate

Vitamin B1 USP/BP/EP  25kg/drum

SKU: 2000kg 类别:
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INQUIRY
Description Thiamine nitrate is an essential vitamin which can enhance normal neuronal actives.
In Vitro Thiamine levels in the blood of homozygous KO and KI mice fed a conventional diet are decreased to 0.058±0.051 and 0.126±0.092 μM, respectively, at 7 weeks compare to WT mice (0.796±0.259 μM). When WT and homozygous KO and KI mice are fed a Thiamine-restricted diet (Thiamine: 0.60 mg/100 g food), blood Thiamine concentration at 5 and 14 days is markedly decreased to 0.010±0.009 and 0.010±0.006 μM, respectively, compare to WT mice (0.609±0.288 μM). Thiamine concentration in brain homogenate of WT mice fed a conventional diet is 3.81±2.18 nmol/g wet weight, and that of KO and KI is 1.33±0.96 and 2.16±1.55 nmol/g wet weight, respectively. Notably, Thiamine concentration in brain homogenate decreases steadily in KO and KI mice fed a thiamine-restrict diet (Thiamine: 0.60 mg/100 g food) for 5 days (0.95±0.72 nmol/g wet weight) and 14 days (1.11±0.24 nmol/g wet weight), respectively, compare to WT (3.65±1.02 nmol/g wet weight), before the mice presenting an phenotype of disease[2].
In Vivo WT, homozygous, and heterozygous KO and KI mice fed a conventional diet (thiamine: 1.71 mg/100 g) survive for over 6 months without any phenotype of disease. Homozygous KO and KI mice fed a Thiamine-restricted diet (thiamine: 0.60 mg/100 g food) show paralysis, weight loss, and immobility, and die within 12 and 30 days, respectively. Similarly, homozygous KO and KI mice fed a Thiamine-restricted diet with an even lower percentage of Thiamine (Thiamine: 0.27 mg/100 g food) die within 14 and 18 days, respectively. However, WT and heterozygous KO and KI mice fed a Thiamine-restricted diet (Thiamine: 0.60 mg or 0.27 mg/100g food) survive for over 6 months without any phenotype of disease[2].
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg

 

1 mM 3.0547 mL 15.2737 mL 30.5474 mL
5 mM 0.6109 mL 3.0547 mL 6.1095 mL
10 mM 0.3055 mL 1.5274 mL 3.0547 mL

Please refer to the solubility information to select the appropriate solvent.

Animal Administration
[2]
Slc19a3 E314Q KI mice are maintained routinely with conventional diet, which has a Thiamine concentration (thiamine hydrochloride, MW=337.3) of 1.71 mg/100 g food. Two types of Thiamine-restrict food base on “purified diets for laboratory rodents” are prepared, in which Thiamine concentration is 0.60 mg/100 g food (35% Thiamine of conventional food) or 0.27 mg/100 g food (16% Thiamine of conventional food). A high-Thiamine-containing food is also prepared from AIN-93M, in which Thiamine concentration is five times that of CE-2 (thiamine: 8.50 mg/100 g food)[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight 327.36
Formula C₁₂H₁₇N₅O₄S
CAS No. 532-43-4
SMILES CC1=C(CCO)SC=[N+]1CC2=CN=C(C)N=C2N.[O-][N+]([O-])=O
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere
Solvent & Solubility DMSO: 15 mg/mL

* “<1 mg/mL” means slightly soluble or insoluble. “≥” means soluble, but saturation unknown.

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Thiamine nitrate-COA wharton

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